宫腔形含铜系列宫内节育器的系统评估

目的 :评估宫腔形含铜系列宫内节育器的有效性、副反应和可接受性。方法 :通过电子和手工检索查阅至2 0 0 2年国内外发表的相关文献 ,按照循征医学的方法进行筛选和评估。结果 :共检索到 39篇相关文献 ,4篇关于宫(药 )铜 2 0 0和 5篇关于宫 (药 )铜 30 0的文献纳入本评估。结果 :宫 (药 )铜 2 0 0IUD与TCu2 2 0CIUD有效性以及 1年、2年累积续用率相似 ;宫铜 30 0IUD有效性与TCu2 2 0CIUD和TCu2 0 0IUD相似 ;宫药铜 30 0IUD有效性与母体乐 375IUD和TCu2 2 0CIUD接近 ,但略差于TCu380AIUD ;宫 (药 )铜 30 0IUD与TCu380AIUD和母体乐 375IUD 1年、3年、5年累积续用率相似。 1年内宫药铜IUD出血副反应较不含药者低。结论 :选择宫铜IUD时宜优先考虑含铜 30 0mm2 的器具 ;需开展TCu380AIUD与宫铜 30 0IUD临床随机对照试验

Uterine Cavity-shaped Device Used in China

Objective: To assess the effectiveness, side effects, and acceptability of copper uterine cavity-shaped intrauterine devices (UCD) with and without indomethacin. Methods: We used electronic search and hand search to identify relevant literatures. Included papers were systematically reviewed according to previous established guidelines. Results: A total of 39 related papers were identified. Of them, 9 papers were included in this review: 4 associated with medicated or non-medicated UCD200 (containing copper 200 mm 2) and 5 associated with medicated or non-medicated UCD300 (containing copper 300 mm 2). Results: The contraceptive effectiveness, cumulative one-year and two-year continuation rates were similar between medicated UCD200, non-medicated UCD200 and TCu220C. The effectiveness of non-medicated UCD300 was similar to that of TCu220C and TCu200. The effectiveness of medicated UCD300 was similar to that of MLCu375 and TCu220C but lower than that of TCu380A. The Cumulative one-year,three-year and five-year continuation rates were similar between medicated, non-medicated UCD300 and TCu380A or MLCu375. The problem of bleeding was less common among medicated UCD users than among non-medicated devices. Conclusions: Uterine cavity-shaped devices should continue to be used in the National Family Planning Programme. However, priority should be given to the 300 mm 2 copper containing device. A large multicenter randomized comparative trial of UCD300 and TCu380A is needed.