电针对庆大霉素耳中毒豚鼠耳蜗内琥珀酸脱氢酶的影响

目的：观察电针对豚鼠庆大霉素耳中毒引起的耳蜗琥珀酸脱氢酶变化的影响。方法：将动物随机分成３组：ＧＥ组动物肌肉注射ＧＥ８０ｍｇ．ｋｇ＾－１．ｄ＾－１，连注射２０天；针刺组肌肉注射ＧＥ同ＧＥ组，每天电针双侧听宫、翳风、肾俞穴１次，持续刺激１５ｍｉｎ；对照组动物不做任何处理。以脑干听觉诱发电位（ＢＡＥＰ０、ＳＤＨ组织检测为观察指标。结果：Ｃ且ＢＡＥＰ和ＳＤＨ两项指标无明显变化；ＧＥ组ＢＡＥＰ反应阈明显升

Effect of Electroacupuncture on Succinate Dehydrogenase of Gentamycin Induced Ototoxic Cochlear Hair Cells in Guinea Pigs

OBJECTIVE: To observe the effect of electroacupuncture (EA) on succinate dehydrogenase (SDH) of gentamycin (GE) induced ototoxic cochlear hair cells. METHODS: Preyer's reflex normal guinea pigs were selected and divided randomly into three groups: GE group, EA group, control group. Brainstem auditory evoked potential (BAEP) and SDH in the cochlear hair cells were taken as indexes. In the animals of GE group GE was alone injected intramuscularly 80 mg.kg-1.d-1 for 20 days, while in the animals of EA group GE and additional EA was applied once a day on Tinggong (SI19), Yifeng(SJ17) and Shenshu (UB23) points. EA lasted for 15 minutes. RESULTS: In the GE group BAEP reaction threshold rose markedly, while that rose slightly in EA group. The difference was significant between two groups (P < 0.05). The change of SDH within cochlear hair cells and degree of hair cells injury in the EA group were lower than those in GE group. CONCLUSIONS: EA therapy could relieve GE ototoxicity, protect SDH in cochlear hair cells and might be a possible mechanism of action of EA.