| 复方甘草酸苷联合拉米夫定治疗膜性乙肝病毒相关肾炎临床研究 |
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| 引用本文： | 郭永兵. 复方甘草酸苷联合拉米夫定治疗膜性乙肝病毒相关肾炎临床研究[J]. 中国现代医学杂志, 2006, 16(14): 2195-2196,2199 |
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| 作者姓名： | 郭永兵 |
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| 作者单位： | 河南省安阳地区医院,河南,安阳,455000 |
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| 摘 要： | 目的 观察联合应用复方甘草酸苷和拉米夫定治疗膜性乙肝病毒相关肾炎的效果。方法 将49例膜性乙肝病毒相关肾炎非大量蛋白尿患者随机分为两组：复方甘草酸苷和拉米夫定组及拉米夫定组，观察两组疗效。结果 1、8周后复方甘草酸苷和拉米夫定组24h尿蛋白定量明显下降（P〈0．01），疗效优于拉米夫定组。2、另外8周后复方甘草酸苷和拉米夫定组ALT明显下降（P〈0．01），Alb明显上升（P〈0．01），疗效优于单用拉米夫定组。结论 复方甘草酸苷和拉米夫定联合治疗膜性乙肝病毒相关肾炎非大量蛋白尿者安全有效，疗效优于单用拉米夫定。
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| 关 键 词： | 乙肝病毒相关肾炎 甘草酸苷 拉米夫定 |
| 文章编号： | 1005-8982（2006）14-2195-02 |
| 收稿时间： | 2006-03-01 |
| 修稿时间： | 2006-03-01 |
Clinical study of glycyrrhizin in combination with lamivudine for treatment of HBV-related nephritis |
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| GUO Yong-bing. Clinical study of glycyrrhizin in combination with lamivudine for treatment of HBV-related nephritis[J]. China Journal of Modern Medicine, 2006, 16(14): 2195-2196,2199 |
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| Authors: | GUO Yong-bing |
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| Affiliation: | Henan Anyang Area Hospital, Anyang, Henan 455000, P.R.China |
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| Abstract: | [Objective] To evaluate the response of glycyrrhizin in combination with lamivudine for the treatment of HBV-related nephritis.[Methods] 49 cases of membranous HBV-related nephritis patients with no-massive proteinuria were randomly treated with glycyrrhizin plus lamivudine(experiment group)and lamivudine(control group).The clinical response between different group were recorded and compared.[Results] 24 hour proteinuria quantitation of patients in experiment group decreased obviously 1 and 8 weeks after treatment,which showed a better therapeutic response than those in control group.In addition,the decrease of ALT and the increase of Alb in experiment group were better than that in control group.[Conclusion] The regimen of glycyrrhizin in combination with lamivudine offers a safe and effective candidate for the treatment of membranous HBV-related nephritis than using lamivudine only. |
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| Keywords: | HBV-related nephritis glycyrrhizin lamivudine |
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