| 氧化应激和阿尔茨海默病 |
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| 引用本文： | 黄艳,董志.氧化应激和阿尔茨海默病[J].中国临床药理学与治疗学,2005,10(5):485-488. |
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| 作者姓名： | 黄艳 董志 |
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| 作者单位： | 重庆医科大学药理教研室,重庆,400016 |
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| 摘 要： | 阿尔茨海默病(Alzheimer’sdisease,AD)是一种以进行性认知功能障碍和记忆力损害为主的中枢神经系统退行性疾病,该病是由多种因素共同作用引起的,其中自由基损伤在发病机理中起重要作用。据报道,抗氧化剂在延缓AD病的进程和改善认知能力上有一定疗效。本文就氧化应激自由基损伤与AD的关系以及抗氧化剂研究现状作一综述。
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| 关 键 词： | 药理学 氧化应激 阿尔茨海默病 自由基 抗氧化剂 |
| 文章编号： | 1009-2501(2005)05-0485-04 |
| 修稿时间： | 2005年3月4日 |
Oxidative stress and Alzheimer's disease |
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| HUANG Yan,DONG Zhi.Oxidative stress and Alzheimer''''s disease[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2005,10(5):485-488. |
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| Authors: | HUANG Yan DONG Zhi |
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| Institution: | HUANG Yan,DONG ZhiDepartment of Pharmacology,Chongqing Medical University,Chongqing 400016,China |
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| Abstract: | Alzheimer's disease (AD) is a kind of neuro-degenerative disease mainly affecting both cognition and behavior, and pathologically characterized by deposition of amyloid-beta peptides as senile plaques and by the occurrence of neurofibrillary tangles (NFT). AD is correlated with many factors, there are several hypotheses about AD, and one of them is oxidative stress and some anti-oxidative drugs demonstrated effective. This paper reviewed the relation between oxidative stress and AD, and the recent study on anti-oxidative drugs for AD. |
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| Keywords: | oxidative stress Alzheimer's disease free radical anti-oxidative drugs |
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