Incidence of pocket hematoma after electrophysiological device placement: dual antiplatelet therapy versus low-molecular-weight heparin regimen |
| |
Authors: | Yan CHEN Yun-Tao LI Ming-Dong GAO Ze-Chun ZENG Jin-Rong ZHANG Hong-Liang CONG Yin LIU Ru ZHAO Le-Feng WANG Xin-Cun YANG and Kang MENG |
| |
Institution: | Department of Cardiology, Tianjin Chest Hospital, Tianjin 300200, China;Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;Department of Cardiology, Tianjin Chest Hospital, Tianjin 300200, China;Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;Department of Cardiology, Tianjin Chest Hospital, Tianjin 300200, China;Department of Cardiology, Tianjin Chest Hospital, Tianjin 300200, China;Department of Cardiology, Tianjin Chest Hospital, Tianjin 300200, China;Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China |
| |
Abstract: | BackgroundGiven the increasing number of patients who require dual antiplatelet (DAP) therapy and electrophysiological device (EPD) placement, perioperative antiplatelet management is a current challenge. In this study, we investigated the incidence of pocket hematoma formation after EPD placement in patients undergoing DAP therapy or an alternative low-molecular-weight heparin (LMWH) regimen.MethodsThis clinical observational study was performed from July 2010 to July 2012. In total, 171 patients were enrolled in the analysis after meeting the inclusion criteria. These patients were divided into two groups: 86 patients were treated with DAP therapy at the time of device implantation, and the DAP therapy was discontinued for 5 to 7 days and replaced with enoxaparin before device implantation in the other 85 patients. Adenosine phosphate (ADP)-mediated platelet aggregation and arachidonic acid-induced platelet aggregation were tested preoperatively. We compared the incidence of pocket hematoma between the two groups and the association of pocket hematoma development with ADP-mediated platelet aggregation and arachidonic acid-induced platelet aggregation.ResultsThe incidence of pocket hematoma in the patients who continued DAP was lower than that in the patients who replaced the dual antiplatelet regimen with LMWH (3.49% vs. 16.47%, respectively; X2 = 6.66, P < 0.01). Among the patients who continued DAP therapies, the rate of ADP-mediated platelet aggregation inhibition in patients with pocket hematomas was higher than that in patients without pocket hematomas. None of the patients undergoing DAP or enoxaparin therapy developed pocket infection, thromboembolic events, or other serious complications. Multiple logistic regression analysis revealed that LMWH therapy was an independent risk factor for the development of pocket hematoma (RR = 0.054, 95%CI = 0.012–0.251). Furthermore, patients undergoing LMWH therapy were 5.1-fold more likely to develop pocket hematomas than were DAP-treated individuals.ConclusionContinuance of DAP therapy does not increase the risk of pocket hematoma formation after EPD placement. |
| |
Keywords: | Antiplatelet drug Hematoma Low-molecular-weight heparin Electrophysiological device |
本文献已被 维普 等数据库收录! |
| 点击此处可从《老年心脏病学杂志(英文版)》浏览原始摘要信息 |
| 点击此处可从《老年心脏病学杂志(英文版)》下载免费的PDF全文 |
|