| 宿主免疫基因多态性与幽门螺杆菌感染相关疾病的关系 |
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| 引用本文： | 郝雯颖,郭明洲,梁浩.宿主免疫基因多态性与幽门螺杆菌感染相关疾病的关系[J].胃肠病学和肝病学杂志,2010,19(4). |
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| 作者姓名： | 郝雯颖 郭明洲 梁浩 |
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| 作者单位： | 中国人民解放军总医院消化内科,北京,100853 |
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| 摘 要： | 幽门螺杆菌(Helicobacter pylori,H.pylori)感染与消化性溃疡、萎缩性胃炎、胃MALT(Mucosa-associated lymphoid tissue)淋巴瘤及胃癌等疾病的发生密切相关。H.pylori感染引起的不同临床结局主要与H.pylori致病因子、宿主因素和环境因素三方面有关。目前宿主基因易感性的差异在H.pylori感染致病的作用已成为研究热点,本文就宿主免疫基因的多态性与幽门螺杆菌感染所致疾病关系的研究进行总结,从宿主TOLL样受体、NOD受体、CD14及HLA等免疫因子基因多态性进行综述。
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| 关 键 词： | 幽门螺杆菌 宿主免疫基因多态性 |
The relationship between host immunogene polymorphism and Helicobacter pylori related disease |
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| HAO Wenying,GUO Mingzhou,LIANG Hao.The relationship between host immunogene polymorphism and Helicobacter pylori related disease[J].Chinese Journal of Gastroenterology and Hepatology,2010,19(4). |
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| Authors: | HAO Wenying GUO Mingzhou LIANG Hao |
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| Institution: | HAO Wenying,GUO Mingzhou,LIANG Hao Department of Gastroenterology,General Hospital of Chinese People\'s Liberation Army,Beijing 100853,China |
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| Abstract: | H.pylori infection may cause many gastroentestinal diseases,such as peptic ulcers,chronic atrophic gastritis,MALT(Mucosa-associated lymphoid tissue) lymphoma and gastric cancer.The different clinical outcome of H.pylori infection is related to H.pylori virulence factors,host factor and environmental factor.The difference of host gene polymorphism may cause different outcome of the H.pylori infection.This review has summarized current researches about the effects of host immunogene polymorphism on gastric di... |
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| Keywords: | H pylori Host immunogene polymorphism |
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