| 小鼠胸腺树突状细胞系MTSC4诱导早期T细胞株C320表达IL－2R |
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| 引用本文： | 张平夏,陈慰峰,陶家平. 小鼠胸腺树突状细胞系MTSC4诱导早期T细胞株C320表达IL－2R[J]. 中华微生物学和免疫学杂志, 1994, 0(3) |
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| 作者姓名： | 张平夏 陈慰峰 陶家平 |
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| 作者单位： | 北京医科大学免疫学教研室 |
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| 基金项目： | 美国洛氏中华医学基金（89－523）,国家自然科学基金 |
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| 摘 要： | 通过流式细胞仪（ＦＡＣＳ）分析了我室自建的小鼠胸腺树突状细胞系ＭＴＳＣ４与小鼠肿瘤性早期Ｔ细胞株Ｃ３２０细胞共育后，Ｃ３２０细胞表达ＩＬ－２Ｒ的状态，分析了ＣｏｎＡ和ＰＨＡ对Ｃ３２０及与ＭＴＳＣ４共育后的Ｃ３２０表达ＩＬ－２Ｒ的诱导促进作用以及ＩＬ－２Ｒ＋Ｃ３２０细胞在脱离外源性刺激后其比例的变化。ＭＴＳＣ４及ＣｏｎＡ和ＰＨＡ在不同程度上抑制Ｃ３２０细胞的无限制增殖，ＣｏｎＡ和ＰＨＡ对与ＭＴＳＣ４共育后的Ｃ３２０细胞的抑制增殖作用更强。
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| 关 键 词： | 小鼠胸腺树突状细胞；早期T细胞；IL－2R |
MOUSE THYMUS DENDRITEC CELL LINE MTSC4 INDUCE IN VITRO PRE-T LYMPHOCYTE CLONE C320 CELLS EXPESSING IL-2R |
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| Zhang Ping -xia,Chen Wei-feng,Tal Jia-ping. MOUSE THYMUS DENDRITEC CELL LINE MTSC4 INDUCE IN VITRO PRE-T LYMPHOCYTE CLONE C320 CELLS EXPESSING IL-2R[J]. Chinese Journal of Microbiology and Immunology, 1994, 0(3) |
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| Authors: | Zhang Ping -xia Chen Wei-feng Tal Jia-ping |
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| Abstract: | The CD25 (IL-2R ,P55)-pgp-1 CD4-CD8- CD3 LFA-1 mouse Pre-T lymphocyte clone C320 could be in-duced to express IL-2R by co-culture with mouse thymic dendritic cell line MTSC4. The fraction of C320 cell re-covered after 7 days and 14 days from these cultures could express IL-2R analysed by FACS. The observation indi-cated that these in vitro gencrated IL-2R C320 cells were responsive to Con A and PHA to express more IL-2R.Cell surface phenotyping suggests that IL-2R pre-T cells are more mature than IL-2R-pte-T cell. The rate ofIL-2R cell was reduced without any exogenous stimulants.MTSC4,Con A and PHA could inhibit unlimited pro-liferation of C320 calls in different degrees. |
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| Keywords: | Mouse thymic dendritic cell Pre-T cell IL-2R |
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