Veränderungen von Mäusenieren nach experimenteller Infektion mit Mucambo-Virus

Summary The purpose of this study was to determine whether autoimmune nephritis in rats affects subsequent generations. Moreover, it was planned to study the nature of the changes in the kidneys in subsequent generations of rats. In these experiments eight generations of rats were investigated. The first five generations were immunized with a mixture of -Streptococcus hemolyticus with an emulsion of renal cortical substance; the rats were given from 4 to 8 injections. After the fifth generation the animals were not immunized, but their nephritis was considerably more pronounced than in their parents. In the 6th and 8th generations there was a sharp rise in the number of animals that died, mainly pregnant rats and newborns. In the course of the experiments, the animals were found to have hypertension, elevated blood nitrogen and proteinuria. A morphological investigation of the rats of the 6th, 7th, and 8th generations that were not immunized, but were born of immunized parents, revealed membranous-proliferative glomerulonephritis, which according to its clinical course and morphological data resembled the nephrotic syndrome the mixed type of human glomerulonephritis.

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Zusammenfassung Die Untersuchungen über den Generationswandel der Autoimmunnephritis der Ratte erstreckten sich über 8 Generationen. Bei den ersten 5 Generationen wurde durch eine 4–8malige Injektion einer Mischung aus beta-hämolytischen Streptokokken mit einer Emulsion aus Nierenrindengewebe eine Immunnephritis erzeugt. Die Ratten der 6. bis 8. Generation erhielten keine immunisierenden Injektionen. Trotzdem kam es in der 6. und 8. Generation zu einem akuten Anstieg der Spontantodesrate besonders unter den graviden und neugeborenen Versuchstieren. Klinisch führte die Immun-Nephritis zu einem Blutdruckanstieg, einer Proteinurie und Erhöhung des Harnstoffes. Histologisch entsprachen die Nierenbefunde der 6.–8. Generation einer membranösen proliferativen Glomerulonephritis.