Apgar评分与CK-MB和cTnI的相关性及临床应用

目的:通过Apgar评分和CK-MB、cTnI含量的测定,为早期评价缺血缺氧性心肌损害并进行干预提供理论依据。方法:记录出生后72 h内的心脏事件并于出生后24 h、72 h、7 d测定不同Apgar评分新生儿血清CK-MB、cTnI含量,然后进行分析。结果:血清CK-MB、cTnI的含量随时间延长逐渐下降(P<0.01),同一时间点在有窒息组和无窒息组之间有显著差异(P<0.01),有窒息组组间也有显著差异(P<0.01),无窒息组组间差异无统计学意义(P>0.05)。心脏事件的发生率随Apgar评分的增加逐渐降低(P<0.01)。Apgar 1 m in评分与CK-MB、cTnI 24 h测定值之间具有很好的相关性(P<0.01)。结论:Apgar评分和CK-MB、cTnI均可作为缺血缺氧性心肌损害的评价指标。

Study on correlation between Apgar and CK- MB , cTnI and its clinical usage

Objective:To provide some theoretical evidences for early evaluating hypoxic-ischemic myocardial injury and giving therapy.Methods:The neonates were selected through Apgar,with 104 newborns as the group of asphyxia and 52 non-asphyxia.The content of CK-MB and cTnI in serum were measured at the time of 24 h,72 h and 7 d after birth.The myocardial events were written out within 72 h after birth.Results:The contents of CK-MB and cTnI decreased gradually with time elongating(P<0.01).There existed a difference(P<0.01) between the groups of asphyxia and non-asphyxia at the given time;while the groups within non-asphyxia had no statistic difference(P>0.05).The ratio of myocardial events decreased with Apgar increasing(P<0.01).There was a good correlation between Apgar by 1 minute and the content of CK-MB、cTnI by 24 hour(P<0.01).Conclusion:Apgar,CK-MB and cTnI can all evaluate hypoxic-ischemic myocardial injury as a criterion..