早期目标导向液体治疗在感染性休克的应用研究

目的探讨早期目标导向液体治疗在感染性休克治疗中的应用。方法将感染性休克患者分为早期复苏组和常规治疗组，分别采用EGDT法和常规液体治疗法进行液体复苏。观察两组患者治疗前后脏器功能受损情况（APACHEⅡ评分）及病死率。结果两组患者在治疗前APACHEⅡ评分差异无统计学意义。治疗后6h轻度脏器功能受损早期复苏组患者的APACHEⅡ评分和病死率明显低于常规治疗组（P〈0．01），而中度和重度水平上两组差异无统计学意义。结论早期液体复苏能较显著地减轻感染性休克患者的脏器功能受损情况和降低病死率。

Early goal-directed fluid therapy in septic shock applied research

Objective To investigate the early goal-directed fluid therapy in the treatment of septic shock applications. Methods In patients with septic shock were divided into early recovery group and the conventional therapy group, respectively EGDT method and conventional liquid treatment for fluid resuscitation, before and after treatment were observed in patients with organ damage（ APACHE Ⅱ score） , and mortality. Results The two groups before treatment in patients with APACHE Ⅱ score difference was not statistically significant. 6 h after treatment with mild organ dysfunction in patients with early recovery group APACHE II score and .mortality rate significantly lower than the conventional therapy group （P〈0.01 ）, while the moderate and severe levels between the two groups no statistical significance. Conclusion The early fluid resuscitation can more significantly reduce the septic shock patients with organ damage and reduce mortality.