| 大黄■虫丸对大鼠肾间质纤维化及TGF-β_1表达的影响 |
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| 引用本文： | 魏连波,马志刚,吕瑞和,郭志坚. 大黄■虫丸对大鼠肾间质纤维化及TGF-β_1表达的影响[J]. 中国中西医结合杂志, 2003, 0(Z1) |
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| 作者姓名： | 魏连波 马志刚 吕瑞和 郭志坚 |
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| 作者单位： | [1]第一军医大学珠江医院中医科 [2]第一军医大学南方医院肾内科 [3]（广州510282） |
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| 摘 要： | 目的:探讨大黄虫丸对腺嘌呤所致人鼠肾间质纤维化及TGF-β_1表达的影响。方法:用腺嘌呤造模,成功后随机分为模型组、中药组和西药组,另设正常组对照。两治疗组分别以大黄虫丸、氯沙坦治疗,检测治疗第3周、6周血肌酐、尿素氮,肾脏过碘酸雪夫(PAS)、Masson染色检测肾间质纤维化程度,利用免疫组化和原位杂交法观察肾脏TGF-β_1,蛋白和TGF-β_1 mRNA 的表达。结果:与模型组比较,中药组、西药组均能改善肾功能,明显减轻间质纤维化程度,同时TGF-β_1蛋白和mRNA 表达下调。中药组作用优于西药组。结论:大黄虫丸可通过下调TGF-β_1表达的作用,改善大鼠肾间质纤维化程度。
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| 关 键 词： | 大黄■虫丸 转化生长因子β_1 肾间质纤维化 慢性肾功能衰竭 |
Effect of Dahuang Zhechong Pill on Kidney Interstitial Fibrosis and TGF-β_1 Expression of Rats |
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| Affiliation: | WEI Lian-bo MA Zhi-gang LU Rui-he Department of Nephropathy; Zhujiang Hospital Affiliated to The First Military Medical University; Guang zhou(510282); |
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| Abstract: | Objective:To explore the effect of Dahuang Zhechong Pill (DZP) on kidney interstitial fibrosis and TGF-β_1 expression of rats. Methods:Rats were randomly divided into model group,TCM group (treated by DZP),WM group (treated by losartan) after suc- cessful modeling by adenine.A normal group was set up as the control.Serum creatine (SCr) and urea nitrogen (BUN) were deter- mined at the 3rd and 6th week.The degree of kidney interstitial fibrosis was examined by periodic aice-Sehiff s (PAS) stain and Masson sta... |
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| Keywords: | Dahuang Zhechong Pill tumor growth factor β_1 kidney interstitial fibrosis chronic renal failure |
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