Multiple Autoantigen Mimotopes of Infectious Agents Induce Autoimmune Arthritis and Uveitis in Lewis Rats |
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| Authors: | Gerhild Wildner and Maria Diedrichs-Moehring |
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| Affiliation: | Section of Immunobiology, Dept. of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany |
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| Abstract: | We found multimolecular antigenic mimicry of arthritogenic autoantigens and peptides from several other “self” or foreign antigens sharing amino acid sequence homologies. Many of these new mimotopes induced arthritis and/or uveitis upon immunization in Lewis rats, indicating a role for multiple antigens in the initiation of a certain autoimmune disease. |
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