注射用丙戊酸钠联合碳酸锂治疗急性躁狂发作的临床疗效

目的通过观察和分析,讨论注射用丙戊酸钠联合碳酸锂治疗急性躁狂发作的临床疗效。方法选取我院自2010年4月-2012年12月期间所得躁狂症并且不断有急性躁狂发作的患者132例,作为本次临床试验的观察对象。先对这132例患者采用碳酸锂进行治疗,若是在4周后病情未控制住,再采用丙戊酸钠联合碳酸锂进行治疗。将全部患者列为对照组,采用联合治疗的患者列为观察组。观察两组患者的好转情况和并发症情况。结果在1周时两组患者的评分无明显差异(P0.05),在2、3、4周后差异有统计学意义(P0.05)。观察组患者的并发症比对照组少33.33%,χ2=5.9183,P0.05,差异具有统计学意义。结论注射用丙戊酸钠联合碳酸锂治疗急性躁狂发作具有显著疗效,并且副作用较少,值得临床广泛应用。

Clinical Effects of Valproate Sodium for Injection Combined with Lithium Carbonate on Treating Acute Manic E pisode

Objectiv e To explore the clinical effects of valproate sodium for injection combined with lithium carbonate on treating a -cute manic episode.Methods From 4.2010 to 12.2012,132 cases of patients with mania and acute manic episode were chosen as the clinical study objects.First,these patients were treated with lithium carbonate .If their condition had been improved after 4 weeks,then combing sodium valproate with lithium carbonate were used to treat them .132 patients were randomly divided into observation group and control group according to random array method .The observation group was treated with sodium valproate for injection combined with lith-ium carbonate ,while the control group was treated with lithium carbonate .The improved situations and complications in the two groups were observed.Results At the 1st week,there was no significant difference between the two groups （P〉0.05）.2,3 and 4 weeks later, there were significant differences .Complication of the observation group was less than that of the control group by 33.33%（χ2=5.9183, P〈0.05）.Concl usion It has obvious curative effects to use valproate sodium for injection combined with lithium carbonate in treating acute manic episode ,with fewer side effects ,which is worth wide clinical using .