精神分裂症伴非酒精性脂肪肝患者血浆瘦素水平

目的探讨瘦素与精神分裂症患者非酒精性脂肪肝(NAFLD)的关系。方法 35例精神分裂症伴NAFLD患者(NAFLD组)测定血浆瘦素;同时测定体质量指数(BMI)、空腹血糖、血脂;以血清甘油三酯和血糖所得简易指数(TyG)评定IR、肝脏超声衰减系数评定NAFLD严重程度,并与35例不伴NAFLD的精神分裂症患者(对照组)进行对照。结果①NAFLD组患者BMI、TG、TC、TyG指数显著高于对照组(t=2.074~8.482,P=0.044~0.000),而HDL-C显著低于对照组(t=2.367,P=0.024);②NAFLD组患者瘦素显著高于对照组(t=7.112,P=0.000),协方差分析调整影响因素后差异仍有显著性(F=5.099,P=0.026);③NAFLD组患者肝脏超声衰减系数值显著高于对照组(t=9.953,P=0.000);④NAFLD组肝脏超声衰减系数值与血浆瘦素水平正相关(r=0.419,P=0.017),偏相关分析调整影响因素后、二者仍正相关(r=0.379,P=0.038)。结论精神分裂症伴NAFLD患者血浆瘦素水平增高,可能与NAFLD的发生机制有关。

Plasma Leptin in Schizophrenia with Non -Alcoholic Fatty Liver Disease

Objective To investigate the relationship between leptin and nonalcoholic fatty liver disease （ NAFLD） in schizophrenia patients.Methods Schizophrenia with or without NAFLD （NAFLD group,n=35;control group,n=35） were tested the level of plasma leptin,body mass index（BMI）,fasting plasma glucose （FPG） and lipids.Index derived from triglycerides and blood glucose （TyG in-dex）,and attenuation coefficient of liver ultrasonography were used for insulin resistance or NAFLD diagnosis and severity assessment re -spectively.Results Schizophrenia with NAFLD cases had significantly higher BMI ,TG,TC and TyG index （ t=2.074~8.482,P〈0.05）and lower HDL-C（t=2.367,P〈0.05）.The plasma level of leptin was significantly higher in NAFLD group than in control group （t=7.112,P〈0.001）.In an analysis of covariance,the difference was still significant after adjusted by influencing factor （F=5.099,P〈0.05）.The attenuation coefficient of liver was significantly higher in cases than in controls （t=9.953,P〈0.001）.There was a positive relationship between plasma level of leptin and attenuation coefficient of liver ,by both simple and partial correlation analysis adjusted by influence（r=0.418,0.379;P〈0.05）.Conclusion Leptin may related to the pathogenesis of NAFLD in patients with schizophrenia .