重组人碱性成纤维细胞生长因子胶囊对大鼠慢性胃溃疡愈合质量的影响

目的　研究rh bFGF对大鼠慢性胃溃疡愈合质量的影响。方法　制备大鼠醋酸性溃疡模型 ,用rh bFGF灌胃治疗 ,待溃疡愈合后继续治疗 10d(共治疗 30d)时取材检查 ,从胃黏膜屏障组织结构和胃黏液屏障两方面评价rh bFGF对大鼠慢性胃溃疡愈合质量的影响。结果　rh bFGF(5 0 0 0～ 10 0 0 0AU·kg-1)可使再生胃黏膜明显增厚 ,降低再生胃黏膜异型程度 ,使再生胃黏膜排列状态接近正常。rh bFGF(2 5 0 0～ 10 0 0 0AU·kg-1)可增加溃疡愈合后瘢痕组织内胶原密度 ,毛细血管密度 ,增加再生胃黏膜表面黏液量、黏多糖层厚度 ,及再生胃黏膜内PGE2 含量。结论　rh bFGF有促进胃黏膜屏障结构成熟 ,提高胃黏液屏障功能 ,提高溃疡愈合质量的作用

Effects of rh-bFGF capsule on quality of chronic gastric ulcer healing in rats

AIM To study the effects of rh bFGF on healing quality of chronic gastric ulcer in rats. METHODS Ulcer model induced by acetic acid was established. Rats were treated with rh bFGF ig until ulcer healing and then continually treated for 10 days(30 total treatment days). The effects of rh bFGF on healing quality of chronic gastric ulcer was evaluated not only from gastric mucoal barrier tissue structure but also from gastric mucus barrier. RESULTS rh bFGF( 5 000 ～ 10 000 AU·kg -1 ) increased the thickness of regenerated gastric mucosa, lowed its abnormity degree and made its align state near to normal. rh bFGF( 2 500 ～ 10 000 AU·kg -1 ) increased collagen and capillary density in scar tissue, added mucus quantity, mucopolysaccharide layer's thickness and PGE 2 content on the surface of regenerated gastric mucosa. CONCLUSION rh bFGF has effects of promoting gastric mucosal barrier to mature, increasing the function of gastric mucus barrier and increasing the quality of ulcer healing.