Estrogen receptors in mammary gland primordia of fetal mouse |
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| Authors: | R. Narbaitz W. E. Stumpf M. Sar |
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| Affiliation: | (1) Department of Anatomy, University of North Carolina, 27514 Chapel Hill, North Carolina, USA;(2) Department of Pharmacology, University of North Carolina, 27514 Chapel Hill, North Carolina, USA;(3) Present address: Department of Anatomy, University of Ottawa, KIN 9A9, Ontario, Canada |
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| Abstract: | Summary Swiss albino mice were injected on day 16 of pregnancy with 3H diethylstilbestrol. Fetuses were sacrificed 3h afterwards, frozen, and processed for thaw-mount autoradiography. The serial sections from 4 fetuses were studied. Intense nuclear concentration of radioactivity was found in the mesenchymal cells directly surrounding the epithelial primordia of the mammary glands, but not in the epithelium itself. Localization was similar in male and female fetuses. These findings are discussed in relation to their developmental, teratological, and oncological implications.Supported by PHS Grant #NS 09914 |
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| Keywords: | Estrogen receptors Mammary gland Diethylstilbestrol Autoradiography |
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