| 大肠癌雌激素受体与孕激素受体表达及临床病理学分析 |
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| 引用本文： | 郭贵然,于世华.大肠癌雌激素受体与孕激素受体表达及临床病理学分析[J].肿瘤研究与临床,1997,9(1):7-9. |
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| 作者姓名： | 郭贵然 于世华 |
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| 作者单位： | 山东省莒县人民医院，莒县中医院，莒县妇幼保健院 |
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| 摘 要： | 应用石蜡切片免疫组织化学ＢＡ法回顾性观察了６８例大肠癌组织雌激素受体（ＥＲ）与孕激素受体（ＰＲ）的表达。结果大肠癌ＥＲ／ＰＲ阳性率为４５．６％和３８．３％，表明癌组织具有ＥＲ／ＰＲ依赖性。其阳性率与患者的年龄、组织学类型有关，年龄越大肿瘤分化程度越高，阳性率越高，与患者性别无关。认为ＥＲ／ＰＲ可作为判别肿瘤的恶性程度及选择内分泌治疗的指标。
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| 关 键 词： | 大肠癌 雌激素受体 孕激素受体 亲合组化BA法 |
EXPRESSION OF ESTROGEN AND PROGESTERONE RECEPTOR IN LARGE INTESTINE CANCER AND CLINICAL PATHOLOGIC ANALYSIS |
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| Guo Guiran,Yu Shihua,Pan Yuezheng,et al..EXPRESSION OF ESTROGEN AND PROGESTERONE RECEPTOR IN LARGE INTESTINE CANCER AND CLINICAL PATHOLOGIC ANALYSIS[J].Cancer Research and Clinic,1997,9(1):7-9. |
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| Authors: | Guo Guiran Yu Shihua Pan Yuezheng |
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| Institution: | Guo Guiran,Yu Shihua,Pan Yuezheng,et al. Ju County People's Hospital |
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| Abstract: | Expression of Estrogen receptor(ER) and Progesterone(PR) in 68 cases with carcinoma of large intestine were observed by immunohistochemistry BA method on paraffin section. The results showed that the positive rates of ER/PR were 45.6%/38.3%. The existence of ER/PR indicated that growth of carcinoma tissues possessed the characteristic of depending on sex hormone. The positive of ER/PR was associated with patient age and type of the tumors. The elder patient age the better differentiation of tumor, the higher positive rates of the ER the PR would be. They were not associated with sex. The high and the low positive levels of the ER and PR were used as deciding malignent degree of the tumors, evaluating prognosis and the choice indicators of endocrinotherapy. |
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| Keywords: | Carcinoma of large intestine Estrogen receptor Progesterone receptor Affinity histochemical method |
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