| BCL—2癌基因蛋白在食管小细胞未分化癌表达的研究 |
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| 引用本文： | 李建民,上原敏敬.BCL—2癌基因蛋白在食管小细胞未分化癌表达的研究[J].肿瘤研究与临床,1997,9(1):26-27. |
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| 作者姓名： | 李建民 上原敏敬 |
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| 作者单位： | 山西省肿瘤医院(李建民)，日本琦玉县立癌中心(上原敏敬)，日本东京老人医疗中心(田久保海誉) |
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| 摘 要： | 应用免疫组织化学方法，对５例食管原发小细胞未分化癌进行原癌基ＢＣＬ－２抑癌基因和抑癌基因Ｂｂ表达的研究。结果表明对ＢＣＬ－２呈过度阳性表达，而对Ｒｂ呈阴性不表达。除１例失访外，其余４例均在１年左右死亡。提示原癌基因ＢＣＬ－２和抑癌基因Ｒｂ在食管原发小细胞未分化癌的发生与发展中，起着介导调节促进细胞增殖的作用。其表达情况可能是肿瘤预后和生物学行为的判断措标。
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| 关 键 词： | BCL－2原癌基因 Rb抑癌基因 食管小细胞未分化癌 |
OVEREXPRESSION OF THE BCL 2 PROTO ONCOGENE IN ESOPHAGEAL SMALL CELL UNDIFFERENTIATION CARCINOMA |
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| Li Jianmin,Toshitak Uehara,T. Takwbo. Shanxi Tumor Hospital.OVEREXPRESSION OF THE BCL 2 PROTO ONCOGENE IN ESOPHAGEAL SMALL CELL UNDIFFERENTIATION CARCINOMA[J].Cancer Research and Clinic,1997,9(1):26-27. |
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| Authors: | Li Jianmin Toshitak Uehara T Takwbo Shanxi Tumor Hospital |
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| Abstract: | The expression of BCL 2 protein and Rb protein in human primary esophageal small cell undifferentiation carcinoma(ESCUC) was investigated by using immunohis tochemistory method. The results showed that overexpression of BCL 2 and negative expression of Rb were seen in all of 5 cases. All the 5 patients were died within about one year. It is suggested that both BCL 2 and Rb may play a role in the regulation of initiation and development of ESCUC, and the expression of the two gene may be an indicator for the prognosis of ESCUC. |
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| Keywords: | Proto oncogene Tumor suppressor gene Small cell undifferetiation carcinoma |
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