Studies of carbachol-induced wet-dog shake behavior in rats |
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| Authors: | Lechoslaw Turski Stanisław J. Czuczwar Waldemar Turski Zdzisław Kleinrok |
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| Affiliation: | (1) Department of Pharmacology, Institute of Clinical Pathology, Medical School, Jaczewskiego 8, 20-090 Lublin, Poland |
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| Abstract: | Intraventricular administration of carbachol chloride evoked wet-dog shakes (WDS) in rats in a dose-related manner. WDS induced by carbachol at the dose of 20  g were antagonized by scopolamine, atropine, cyproheptadine, morphine, clonidine, phentolamine, haloperidol, and l-5-hydroxytryptophan (5-HTP).Methergoline, propranolol, bicuculline, and aminooxyacetic acid had no effect on carbachol-induced shaking behavior. The present experiments show the existence of different types of shaking behavior, not exclusively related to the stimulation of central 5-HT structures. |
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| Keywords: | Carbachol Wet-dog shakes |
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