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恶性肿瘤患者和正常人外周血单个核细胞培养上清SIL-2R水平的动态变化
引用本文:王树宽,樊春梅,笪玉,冷南,吴振彪,解慧,陈龙邦. 恶性肿瘤患者和正常人外周血单个核细胞培养上清SIL-2R水平的动态变化[J]. 医学争鸣, 1994, 0(3)
作者姓名:王树宽  樊春梅  笪玉  冷南  吴振彪  解慧  陈龙邦
作者单位:西京医院临床免疫科
摘    要:作者测定20例恶性肿瘤患者和20例正常人血清中SIL-2R水平,并对其外周血单个核细胞(PBMC)不加激活剂培养,加PHA培养及加rIL-2培养后3种情况上清中SIL-2R水平的动态变化进行测定.结果表明,恶性肿瘤患者血清中SIL-2R水平比正常人显著升高(P<0.01);恶性肿瘤患者和正常人的PBMC不加激活剂培养的上清中SIL-2R水平均略有增加,且正常人高于恶性肿瘤患者.加PHA或者加rIL-2激活培养的上清中SIL-2R水平上升很高,PHA激活培养的PBMC上清中SIL-2R水平要比rIL-2激活的PBMC培养上清中SIL-2R水平上升的快.但恶性肿瘤患者与正常人PBMC在各种条件激活培养的上清中SIL-2R水平无显著差异.

关 键 词:外周血单个核细胞,重组白细胞介素2,可溶性IL-2受体

Dynamic comparison of supernatants of peripheral blood mononucle-ar cell culture between malignant tumor patients and normal donors
WANG Shu-Kuan,FAN Chun-Mei,DA Yu-Ming,LENG Nan,WU Zhen-Biao,XIE Hui and CHEN Long-Bang. Dynamic comparison of supernatants of peripheral blood mononucle-ar cell culture between malignant tumor patients and normal donors[J]. Negative, 1994, 0(3)
Authors:WANG Shu-Kuan  FAN Chun-Mei  DA Yu-Ming  LENG Nan  WU Zhen-Biao  XIE Hui  CHEN Long-Bang
Affiliation:WANG Shu-Kuan,FAN Chun-Mei,DA Yu-Ming,LENG Nan,WU Zhen-Biao,XIE Hui and CHEN Long-BangDepartment of Clinical Immunology,Xijing Hospital
Abstract:Serial determinations of soluble interleukin-2 receptor(SIL-2R)levels in sera and supernatants ofperipheral blood mononuclear cell ( PBMC )cultures with PHA or rlL-2 or without any of the stimulantsadded were carried out.The results showed that SIL-2R levels in sera of malignant tumor patients were sig-nificantly higher than those of normal donors.SIL-2R levels in the supernatants of PBMC cultures withoutstimulants from both malignant tumor patients and normal donors were slightly elevated, with the latter rela-tively higher than the former.SIL-2R levels in the supernatants of PBMC cultures with PHA or rIL-2 weremarkedly increased,with the former being increased more rapidly t han the latter while no significant differ-ence was observed between that from malignant tumor patients and normal donors.
Keywords:peripheral blood mononuclear cell  recombinant interleukine 2  soluble interleukine 2 receptor  
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