TGF β1 and PDGF AA override Collagen type I inhibition of proliferation in human liver connective tissue cells |
| |
| Authors: | Alvaro T Geremias Marcelo A Carvalho Radovan Borojevic and Alvaro NA Monteiro |
| |
| Institution: | (1) Departamento de Bioqu?mica, Instituto de Qu?mica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949, Brazil;(2) Laborat?rio de Metabolismo Macromolecular Firmino Torres de Castro, Instituto de Biof?sica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941, Brazil;(3) Departamento de Histologia e Embriologia, Instituto de Ci?ncias Biom?dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941, Brazil |
| |
| Abstract: | Background A marked expansion of the connective tissue population and an abnormal deposition of extracellular matrix proteins are hallmarks
of chronic and acute injuries to liver tissue. Liver connective tissue cells, also called stellate cells, derived from fibrotic
liver have been thoroughly characterized and correspond phenotypically to myofibroblasts. They are thought to derive from
fat-storing Ito cells in the perisinusoidal space and acquire a contractile phenotype when activated by tissue injury. In
the last few years it has become evident that several peptide growth factors such as PDGF AA and TGF-β are involved in the
development of fibrosis by modulating myofibroblast proliferation and collagen secretion. The fact that during the development
of chronic fibrosis there is concomitant deposition of collagen, a known inhibitory factor, and sustained cell proliferation,
raises the possibility that stellate cells from chronic liver fibrosis patients fail to respond to normal physiologic controls. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
