Impaired defense against vaccinia in a child with T-lymphocyte deficiency associated with inosine phosphorylase defect. |
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Authors: | J L Virelizier M Hamet J J Ballet P Reinert C Griscelli |
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Affiliation: | 1. Groupe de Recherches d''Immunologie et de Rhumatologie Pédiatriques, INSERM U 132, Hôpital des Enfants Malades, Paris, France;2. Groupe de Recherches d''Enzymologie Médicale, INSERM U 75, Faculté de Médecine Necker-Enfants Malades, Paris, France |
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Abstract: | A case of progressive vaccinia associated with a profound deficiency of cellular immunity and a defect in inosine phosphorylase is described. A striking contrast was observed between humoral immunity, which showed little if any impairment, and a severe cellular defect affecting both markers and functions of T lymphocytes. The child died despite treatment with methosazone, levamisole, transfer factor, irradiated blood transfusions, and a thymus graft. An adequate serum level of antibody to vaccinia virus was obtained by transfer of specific immunoglobulins, but this failed to stop the progression of the disease. This observation suggests that host defense against vaccinia infection is mainly mediated by cellular immunity. |
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Keywords: | Reprint address: Unitè d'Immuno-Hématologie Hôpital des Enfants Malades 149 Rue de Sèvres 75730 Paris Cedex 15 France. |
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