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The effect of vasopressin on the cytoskeleton of the epithelial cell |
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| Authors: | Richard M. Hays John Condeelis Yang Gao Herold Simon Guohua Ding Nicholas Franki |
| Affiliation: | (1) Department of Medicine, Division of Nephrology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann Building Room 617, 10461 Bronx, NY, USA;(2) Department of Anatomy/Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann Building Room 617, 10461 Bronx, NY, USA |
| Abstract: | Vasopressin (AVP) promotes the fusion of vesicles containing water channels with the apical membrane of receptor cells in the amphibian bladder and mammalian kidney. Fusion is accompanied by depolymerization of the actin cytoskeleton. In this review, we present the evidence for actin depolymerization by AVP in the whole cell, and the application of confocal microscopy and immunogold electron microscopy in localizing depolymerization to the apical region of the receptor cell. |
| Keywords: | Vasopressin Actin Cytoskeleton Urine concentration |
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