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| XK的镇痛作用及急性毒性的时间药理学研究 | |
| 引用本文： | 朱玲,周黎明,孙爱民,包定元,刘延友,范爱兰,王正荣. XK的镇痛作用及急性毒性的时间药理学研究[J]. 中国药理学通报, 2005, 21(3): 306-309 |
| 作者姓名： | 朱玲 周黎明 孙爱民 包定元 刘延友 范爱兰 王正荣 |
| 作者单位： | 1. 四川大学华西基础与法医学院药理学教研室,四川,成都,610041 2. 四川大学生物医学与工程研究室,四川,成都,610041 3. 四川大学分析测试中心,四川,成都,610041 |
| 摘 要： | 目的研究XK对小鼠的急性毒性、药效学及药动学的昼夜节律性。方法小鼠分别在0400、0800、1200、1600、2000和2400灌胃XK后,观察其急性死亡率,用热板法、扭体法了解XK镇痛作用的时间变化,同时用高效液相色谱法测定不同时间点的血药浓度。结果XK对小鼠的急性毒性呈明显的昼夜节律,毒性作用的峰值在明中期;镇痛作用存在昼夜节律性差异,但作用峰值在明中后期,这恰是血药浓度的达峰时间。结论XK有良好的镇痛作用,其急性毒性和镇痛作用均呈现昼夜节律性,急性毒性与血药浓度的昼夜节律性有关。 |
| 关 键 词： | XK镇痛药物 高效液相色谱法 时间药理学 |
| 文章编号： | 1001-1978(2005)03-0306-04 |
| 修稿时间： | 2004-05-11 |
Study of XK on the chronopharmacology in mice |
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| ZHU Ling,ZHOU Li-ming,SUN AI-MIN,BAO Ding-yuan,LIU Yan-you,FAN Ai-lan,WANG Zheng-rong. Study of XK on the chronopharmacology in mice[J]. Chinese Pharmacological Bulletin, 2005, 21(3): 306-309 | |
| Authors: | ZHU Ling ZHOU Li-ming SUN AI-MIN BAO Ding-yuan LIU Yan-you FAN Ai-lan WANG Zheng-rong |
| Abstract: | Aim To study the circadian rhythm in mice of XK. Methods Hot plate procedure and irritation by acetic acid were employed to study analgesic effect. To observe the variety of acute toxicity and the analgesic effect, high performance liquid chromatography was used to measure blood concentration of XK at 04:00,08:00,12:00,16:00,20:00 and 24:00 after administered.Result The acrometron of XK’s acute toxicity was in the middle of light period;The acrometron of analgesic effect and the blood concentration of XK also was in the middle or rearward of light period.Conclusion Obvious circadian rhythm was observed for acute toxicity and analgesic effects of XK in mice.It was related to the circadian rhythm of the blood concentration for XK. |
| Keywords: | XK analgesic drug HPLC chronopharmacology |
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