香椿总黄酮降血糖作用的实验研究

目的:研究香椿总黄酮(TSTF)对糖尿病小鼠动物模型的降血糖作用.方法:将四氧嘧啶用NS配成0.02 g/ml,按200 mg/kg注射到小鼠腹腔;连续2 d用葡萄糖灌胃(2 g/kg),早晚各一次,以葡萄糖氧化酶法测空腹血糖,大于11.00 mmol/L为造模成功小鼠.将入选小鼠随机分为模型组、TSTF低、高剂量组(0.06、0.12 g/kg)、降糖灵组(0.10 g/kg),另取20只正常小鼠为对照组(蒸馏水),灌胃1次/d,连续15 d,第16 d用葡萄糖氧化酶法测空腹血糖.结果:TSTF组四氧嘧啶小鼠血糖显著降低.结论:TSTF对四氧嘧啶所敛糖尿病模型小鼠有降血糖作用.

Experimental Studies on Hypoglycemic Effects of Total Flavonoid from Toona sinensis

Objective: To study hypoglcemic effects of total flavonoid from Toona sinensis(TSTF) on diabetic mice model.Methods: To confect alloxan 0.02 g/ml with NS and injected alloxan into abdominal cavity to induce diabetic model,and all rats were fed bid with glucose for 2 consecutive days,then the blood glucose was detected by glucose oxidizes,when hypoglycemic point>11.00 mmol/L the rats were successful model made.100 model rats were divided into 5 groups as contrast groups(distilled water),model control control groups,hight doses group(0.12 g/kg)and low doses group(0.6 g/kg) of TSTF,positive control groups of phenformin(0.10 g/kg);In addition to set 20 natural rats(distilled water),and all groups were fed qd for 15 consecutive days,and then the blood glucose were detected by glucose oxidizes in the sixteenth day.Results:The blood glucose levels of the diabetic rats in TSTF groups significantly decreased.Conclusion: TSTF can significantly decrease the blood glucose levels of diabetic mice induced by alloxan.