高敏肌钙蛋白I在不稳定型心绞痛严重程度及预后评估中的应用

目的 探讨高敏肌钙蛋白I(hs-cTnI)检测在不稳定型心绞痛(UAP)患者的诊断、冠状动脉病变严重程度及短期预后判断等方面中的应用.方法 102例常规血清cTnI阴性的UAP患者,冠状动脉造影前测定血清hs-cTnI水平,随访30 d,记录心血管不良事件.结果 hs-cTnI水平随着冠脉病变的严重程度而升高,hs-cTnI水平越高,冠脉狭窄程度及病变累及血管的程度越严重,差异有统计学意义(P＜0.05).hs-cTnI升高组主要心血管事件发生率明显高于hs-cTnI正常组,差异有统计学意义(P＜0.01).结论 hs-cTnI水平的高低可预测冠脉病变的狭窄严重程度与病变范围,其升高提示短期预后不佳、主要心血管事件发生率增加,可作为UAP早期危险分层的一个指标.

Severity and prognosis evaluation of serum high sensitivity cardiac troponin I in unstable angina pectoris

Objective To explore the application of serum high sensitivity cardiac troponin I(hs-cTnI) detection in clinical diagnosis,coronary artery disease severity and short-term prognostic in unstable angina pectoris(UAP) patients.Methods 102 UAP patients with cTnI negative were selected.Serum hs-cTnI was measured before coronary angiography,and was followed-up to 30 days.The main cardiovascular events was recorded.Results Serum hs-cTnI levels increased with the degree of coronary artery disease.The levels of serum hs-cTnI were higher,coronary stenosis and vascular lesions were more serious(P<0.05).The incidence of short-term cardiovascular events in patients with elevated serum hs-cTnI was significantly higher than that of normal group(P<0.01).Conclusion Serum hs-cTnI levels may predict the severity of coronary and the major cardiovascular events.It may be used as an early risk stratification in UAP.