HIV合并结核分枝杆菌感染的探索研究

目的 了解该地区HIV合并结核分枝杆菌(TB)感染的发展状况.方法 随机选取2008年1月至2010年12月在该院检查并接受治疗的177例HIV感染者作为调查对象,统计这些病例中感染TB的例数,分析该地区HIV感染者合并TB感染的百分率,并进行TB药敏分析.结果 在177例HIV感染患者中有29例患者合并感染TB,占16.38%,其中男21例,占72.41%(21/29),女8例,占27.59%(8/29),差异有统计学意义(P<0.01).而在29例HIV合并TB感染患者中,TB对利福平、乙胺丁醇、链霉素、异烟肼的敏感性分别为100.00%、100.00%、89.65%、75.86%.结论 HIV合并TB感染是HIV患者死亡的最重要因素,在临床中应加强检测并合理使用抗菌药物和抗病毒药物,以减少HIV感染者的病死率.

Research on infection status of HIV combined with Mycobacterium tuberculosis

Objective To understand the status of HIV /AIDS and Mycobacterium tuberculosis(TB) infection.Methods 177cases of patients with HIV infection,diagnosed and treated in this hospital during Jan.2008and Dec.2010,were randomly selected and surveyed for the infection status of TB to analyze the mixed infection rate of HIV and TB.The drug susceptibility of TB was also analyzed.Results In 177cases of patients with HIV infection,29cases were with combined infection of TB,accounting for 16.38%,21cases of male,accounting for 72.41%,and 8cases of female,accounting for 27.59%,and the mixed infection rate was different between male and female patients(P<0.01).Among the 29cases with mixed infection of HIV and TB,the sensitivity rates of TB to rifampicin,ethambutol,streptomycin and isoniazid were 100.00%,100.00%,89.65% and 75.86%.Conclusion Mixed infection of HIV and TB might be the most important factor casing the death of HIV patients.In clinical practice,it should be strengthened to detect and rational use of antibiotics and antiviral drugs to reduce the mortality of HIV infected persons.