386例假丝酵母菌菌种分布及药敏结果分析

目的 分析假丝酵母菌属临床感染的种类分布及药物耐药性.方法 采用VITEK-AMS全自动微生物鉴定系统、酵母样真菌鉴定卡YBC进行鉴定和药敏实验.结果 所分离的386例假丝酵母菌属中,白色假丝酵母菌占第一位,为64.2%;其次为热带假丝酵母菌,占20.7%;白色假丝酵母菌对唑类的耐药率较低(氟康唑0.6%,酮康唑1.2%);热带假丝酵母菌对唑类的耐药率较白色假丝酵母菌高(氟康唑6.2%,酮康唑7.5%);光滑假丝酵母菌对唑类的耐药率较高(氟康唑16.7%,酮康唑13.3%);克柔假丝酵母菌对氟康唑的耐药率达84.2%.结论 假丝酵母菌属的感染种类不断增多,耐药性上升,对易感患者应加强监测,分析发病原因,合理应用抗菌剂,以延缓和防止真菌耐药性的进一步发展.

Species distribution and drug resistance of 386 strains of candida

Objective To analyze the species distribution and drug resistance of clinical isolates of candida.Methods Clinical isolates were identified and detected for drug susceptibility by using VITEK-AMS automated microbial identification system and yeast-like fungi identification card YBC.Results Among 386 strains of Candida mycoderma,the most common specie was Candida albicans with the proportion of 64.2%,followed by Candida tropicalis(20.7%).Candida albicans was sensitive to azoles,with resistance rate of 0.6% and 1.2% to fluconazole and ketoconazole.Candida tropicalis was more resistant to azoles than Candida albicans,with resistance rate of 6.2% to fluconazole and 7.5% to ketoconazole.Candida glabrata was highly resistant to azoles,with resistance rate of 16.7% and 13.3% to fluconazole and ketoconazole.The resistance rate of Candida krusei to fluconazole was 84.2 %.Conclusion Many species of candida could cause infections,with the increasing of drug resistance.Monitoring on susceptible patients should be strengthened for the analysis of etiology and rational use of antimicrobial drugs to prevent and delay further development of drug resistance.