208例肺结核患者凝血功能变化的临床意义

目的 分析5项凝血指标以及血小板计数(Plt)在肺结核患者治疗前、后变化情况及其诊断肺结核的临床意义.方法 采用Sysmex CS-2000i全自动凝血分析仪对2009年1月至2011年11月该院确诊的208例肺结核患者治疗前、后和50例健康体检者(对照组)凝血酶原时间(PT)、活化部分凝血时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fg)、D-二聚体以及Plt进行检测,并进行相关统计学分析和处理.结果 肺结核患者治疗前与对照组比较,TT延长,Fg、Plt、D-二聚体升高(P<0.05),PT和APTT与对照组比较,差异无统计学意义(P>0.05);经常规化疗1个疗程后患者Plt趋于正常,TT和Fg下降,治疗后各项指标与对照组比较,差异无统计学意义.结论 肺结核患者凝血功能变化与治疗前、后相关,并且与治疗效果相关,可作为肺结核诊治监测的辅助手段.

Changes of blood coagulation function in 208 cases of tuberculosis patients and its clinical significance

Objective To analyze the changes of 5 items of blood coagulation function and platelet counting in patients with tuberculosis before and after treatment and related clinical significance for the diagnosis of tuberculosis.Methods Sysmex CS2000i hemoglutanation analyzer was used to measure prothrombin time(PT),activated partial thrombopastin time(APTT),thrombin time(TT) fibrinogen(Fg),D-Dimer(DD) and platelet counting(Plt) in 50 healthy controls(control group) and 208 patients with definite diagnosis of tuberculosis in this hospital before and after treatment from Jan.2009 to Nov.2011.All data were then statistically analyzed.Results There was statistical difference of TT,Fg and Plt between patient group,detected before treatment,and control gorup(P<0.05),but no statistical difference of PT and APTT could be demonstrated(P>0.05).After a course of routine treatment,there was no statistical difference of the detected results of all indicators between patient group and control group(P>0.05).Conclusion The function of blood coagulation might be correlated with treatment effects,and detection of blood coagulation function could serve as an auxiliary strategy for the diagnosis and monitoring of therapeutic efficacy in tuberculosis patients.