人血清载脂蛋白M与血脂的相关性研究

目的 探讨血浆中载脂蛋白M(ApoM)水平与总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平的相关关系.方法 用ELISA法检测200例随机人群血清(男101例,女99例)中ApoM水平,酶法检测其TC、TG、HDL-C 和LDL-C水平,分析ApoM与各项目之间的相关性.结果 男女混合分析显示ApoM与TC水平呈正相关(r=0.418,P<0.01),与TG水平呈负相关(r=-0.407,P<0.01)同时与HDL-C呈正相关(r=0.786,P<0.01),与HDL-C/TC呈正相关(r=0.671,P<0.01).结论 血浆中ApoM水平与TC、HDL-C水平呈正相关,与TG水平呈负相关,提示ApoM在血脂代谢中有一定的生理功能.

Study of the relationship between apolipoprotein M and blood lipid

Objective To explore the correlation between apolipoprotein M(apoM) and other blood lipid indicators such as total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C).Methods Plasma levels of apoM were measured by ELISA in 200 outpatients(101 male and 99 female).The levels of TC,TG,HDL-C and LDL-C were measured by enzymatic method.The correlation between ApoM and other blood lipid indicators was analyzed.Results Male and female data mixed analysis showed that ApoM was significantly and positively correlated with TC(r=0.418,P<0.01),HDL-C(r=0.786,P<0.01) and HDL-C/TC(r=0.671,P<0.01),and negatively related to TG(r=-0.407,P<0.01).Conclusion Level of ApoM is significantly and positively correlated with TC,HDL-C and HDL-C/TC,respectively,while it is negatively correlated with TG.It suggests that ApoM may play a role in the metabolism of lipid.