抗CCP抗体、RF、CRP、ESR在类风湿关节炎诊断中的应用价值

目的 探讨抗环瓜氨酸肽(CCP)抗体、类风湿因子(RF)、C反应蛋白(CRP)、红细胞沉降率(ESR)在类风湿关节炎(RA)诊断中的意义.方法 选择RA患者42例(RA组),非RA疾病患者34例(非RA组),健康对照组21例,分别采用微粒子酶免疫分析法(MEIA)检测抗CCP抗体,用速率散射比浊法检测RF、CRP,采用Westergren法检测ESR.比较各组之间RF、抗CCP抗体有无显著性差异,同时对RA组抗CCP抗体、RF、ESR、CRP的相关性进行分析.结果 抗CCP抗体对RA的敏感度为76.2%(32/42),特异度为98.2%(54/55);RF对RA的敏感度为81.0%(34/42),特异度为90.9%(50/55);抗CCP抗体与CRP、ESR均无相关性(P>0.05),RF与CRP、ESR均无相关性(P>0.05).结论 抗CCP抗体的敏感度较RF低,但特异度比RF高;与CRP、ESR无相关性.

Research of the diagnostic value of anti cyclic citrullinated peptide antibodies,rheumatoid factor,C-reactive protein and erythrocyte sedimentation rate in rheumatoid arthritis patients

Objective To investigate the application of anti cyclic citrullinated pep tide(anti-CCP) antibodies,rheumatoid factor(RF),C-reactive protein(CRP),and erythrocyte sedimentation rate(ESR) in the diagnosis of rheumatoid arthritis(RA).Methods RA group(42 cases of patients),non-RA disease group(34 cases of patients) and normal control group(21 cases of healthy people) were randomly collected.Microparticle enzyme immunoassay(MEIA) was used to determine anti-CCP antibodies.RF and CRP were measured by scattering rate turbidimetry.ESR was measured by Westergren method.The difference between RF and anti-CCP antibodies was compared,and the correlation of anti-CCP antibodies,RF,ESR,and CRP in RA group was also analyzed.Results The diagnostic sensitivity of anti-CCP antibody for RA was 76.2% and the specificity was 98.2%,whereas the diagnostic sensitivity of RF was 81.0% and the specificity was 90.9%.Anti-CCP antibody titer was non-correlated with ESR and CRP in RA group(P>0.05).RF was non-correlated with ESR and CRP in the same group either(P>0.05).Conclusion The sensitivity of anti-CCP antibody is lower than that of RF in RA group,but its specificity is higher.There is no correlation between anti-CCP antibody titer and RA serum indicators of activity indicators such as CRP and ESR.