珠蛋白生成障碍性贫血患者中葡萄糖-6-磷酸脱氢酶活性的调查

目的 研究不同类型珠蛋白生成障碍性贫血(简称地贫)患者中葡萄糖-6-磷酸脱氢酶(G6PD)的活性.方法 采用G6PD活性定量测定,血常规和血清铁蛋白检测对人群进行初筛,同时采用全自动琼脂糖凝胶电泳检测初筛人群的α-地贫以及β-地贫类型,并对其G6PD活性值进行相关统计学分析.结果 健康人群、单纯缺铁性贫血、缺铁性贫血合并地贫、轻型α-地贫、轻型β-地贫、重型β-地贫、血红蛋白H(HbH)病以及α-地贫合并β-地贫各组间G6PD活性差异有统计学意义(P<0.05).结论 各类型地贫患者的G6PD活性有不同程度的升高,对地贫的辅助诊断有一定的价值.

Investigation of G6PD activity in patients with thalassemia

Objective To investigate the activity of glucose-6-phosphate dehydrogenase(G6PD) in patients with different types of thalassemia.Methods G6PD activity,blood cell counts and serum ferritin were detected for preliminary screening,and full-automatic agar gel analyzer was used to confirm the type ofα-or β-thalassemia.G6PD activity of all subjects were statistically analyzed.Results There were statistical difference of G6PD activity between healthy subjects and patients with iron deficiency anemia(IDA),IDA combined thalassemia,α-thalassemia minor,β-thalassemia minor,β-thalassemia major,hemoglobin H(HbH) disease and αcombine β-thalassemia(P<0.05).Conclusion The G6PD activity in patients with various types of thalassemia might be increased for different degree.It might be with certain value for auxiliary diagnosis of thalassemia.