195株铜绿假单胞菌的临床分布及耐药性分析

目的 了解该院铜绿假单胞菌临床来源及耐药情况,以指导临床合理用药.方法 收集该院2010年1~12月临床分离的铜绿假单胞菌,采用WHONET5.4软件分析.结果 共分离铜绿假单胞菌195株,其中从痰标本中分离121株(62.05%),分泌物中分离50株(25.64%);呼吸内科分离55株(28.21%),脑外科分离45株(23.08%).其对美罗培南耐药率最低(6.27%),对左氧氟沙星、环丙沙星、头孢吡肟耐药率也较低,分别为11.28%、13.85%、19.49%.结论 铜绿假单胞菌易产生多重耐药性,必须加强耐药监测,为临床用药提供指导.

Clinical distribution and drug resistance analysis of 195 strains of Pseudomonas aeruginosa

Objective To get information of clinical distribution and drug resistance of Pseudomonas aeruginosa in this hospital.Methods Clinical strains of Pseudomonas aeruginosa isolated during January,2009 to December 2010 were collected.The data were analyzed by WHONET5.4 software.Results 195 strains of Pseudomonas aeruginosa were isolated,among which 121 strains(62.05%) were isolated from sputum,50 strains(25.64%) from secretions,55 strains(28.21%) from Department of Respiratory Medicine and 45 strains(23.08%) from Department of Cerebral Surgery.Drug resistance rate of the clinical isolates to Meropenem were the lowest(6.27%),to Levofloxacin,Ciprofloxacin and Cefepime relatively lower,with 11.28%,13.85% and 19.49% for each.Conclusion It might be easy of Pseudomonas aeruginosa to acquire multi-drug resistance.Monitoring of drug resistance should be strengthened to provide guidance to clinics for rational usage of antibiotics.