烧伤创面感染病原菌调查及耐药性分析

目的 探讨烧伤创面感染菌分布及耐药性情况,为临床用药提供参考.方法 对烧伤创面细菌培养及药敏结果进行回顾性分析.结果 革兰阴性杆菌占82.3%,革兰阳性球菌占17.7%,未检出真菌.铜绿假单胞菌占33.1%,大肠埃希菌占15.3%,奇异变形杆菌占11.3%;金黄色葡萄球菌占8.1%.其中大肠埃希菌ESBLs分离率为57.9%,耐甲氧西林金黄色葡萄球菌(MRSA)的分离率为80.0%,亚胺硫霉素对肠杆菌无一例耐药,万古霉素、利奈唑胺对葡萄球菌无一例耐药.结论 该院烧伤病房感染菌以革兰阴性杆菌为主,革兰阳性球菌次之.耐药率增加的问题不容忽视.亚胺硫霉素应作为抗革兰阴性杆菌和革兰阳性球菌的首选药物,万古霉素和利奈唑胺作为抗革兰阳性球菌首选药物.

Investigation of pathogenic bacteria causing burn wound infection and analysis of drug-resistance

Objective To study the distribution and drug-resistance of bacteria causing burn wound infection.Methods Results of culture and drug susceptibility of bacteria causing burn wound infection were retrospectively analyzed.Results The isolation rates of Gram negative bacilli,Gram positive coccus and fungi were 82.3%,17.7% and 0.0%.In pathogenic Staphylococcus aureus,the isolation rate of methicillin resistant Staphylococcus aureus was 80.0%.Isolation rates of Pseudomonas aeruginosa,Escherichia Coli and Proteus mirabilis were 33.1%,15.3% and 11.3%.No imipenem-resistant Enterobacter was found.No vancomycin and linezolid-resistant Staphylococcus was found.Conclusion Gram negative bacilli might be the main pathogenic bacteria causing burn wound infection,followed by Gram positive coccus.Drug-resistance might be raising.Imipenem could be the first chosen antibiotic to treat Gram negative bacilli inifection.Vancomycin and linezolid could be the first chosen antibiotic to treat Gram positive coccus infection.