进展性缺血性脑卒中患者血清MMP-9和ox-LDL水平的检测及临床意义

目的 探讨进展性缺血性脑卒中(PIS)患者血清基质金属蛋白酶-9(MMP-9)和氧化低密度脂蛋白(ox-LDL)的水平.方法 分别于急性缺血性脑卒中起病后第1、3、5、7天动态监测100例PIS(PIS组)与113例完全性缺血性卒中组(非PIS组) 血清MMP-9和ox-LDL水平.结果 PIS组和非PIS组血清MMP-9与ox-LDL水平第1天到第3天有升高趋势,第5天开始回落;起病后第1、3、5和7天血清MMP-9与ox-LDL水平PIS组均高于非PIS组(P<0.01).结论 MMP-9和ox-LDL共同参与了PIS的病理生理过程,而MMP-9和ox-LDL通过相应机制造成血管内皮损伤和功能障碍,可能是造成PIS患者神经功能缺损症状逐步进展的原因.

Determination of MMP-9 and ox-LDL in patients with progressive ischemic stroke

Objective To explore the level changes of matrix metalloproteinase-9(MMP-9) and oxidized low-density lipoprotein(ox-LDL) in acute period of progressive ischemic stroke(PIS).Methods 100 patients with PIS who attained the diagnostic principle(PIS group) and 113 patients with total ischemic stroke(non-PIS group) were enrolled.Serum levels of MMP-9 and ox-LDL were measured by double antibody enzyme-linked immunosorbent assay(ELISA)method.Results The serum levels of MMP-9 and ox-LDL in PIS group and non-PIS group increased to the top on the third day.The serum levels of MMP-9 and ox-LDL in PIS group were higher than those in non-PIS group on the first,third,fifth and seventh day(P<0.01).Conclusion It is suggesting that metabolic disorder of MMP-9 and ox-LDL maybe plays a role in PIS.The increase of serum MMP-9 and ox-LDL levels probably lead to the increasing of NIHSS degree in patients with PIS.