| 血清CK18及CA72-4水平在胃癌诊治中的临床价值 |
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| 引用本文： | 杨士军,陆卫平,鲍艳梅,吴茜.血清CK18及CA72-4水平在胃癌诊治中的临床价值[J].国际检验医学杂志,2012,33(13):1593-1594. |
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| 作者姓名： | 杨士军 陆卫平 鲍艳梅 吴茜 |
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| 作者单位： | 1. 南京医科大学附属淮安第一医院核医学科,江苏淮安,223300
2. 南京医科大学附属淮安第一医院内分泌科,江苏淮安,223300 |
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| 摘 要： | 目的 探讨血清细胞角蛋白18(CK18)和糖类抗原72-4(CA72-4)水平在胃癌患者临床诊治中的价值.方法 分别采用酶联免疫吸附(ELISA)法和电化学发光法检测89例胃癌患者手术前、后血清CK18和CA72-4水平,并与胃良性病变患者35例及健康对照组37例进行对比分析.结果 血清CK18和CA72-4水平胃癌组高于胃良性疾病组和健康对照组,差异有统计学意义(P<0.01);胃癌手术前组高于手术后组,差异有统计学意义(P<0.01);有淋巴结转移组高于无淋巴结转移组,差异有统计学意义(P<0.01).在胃癌组中行根治性手术患者术后血清CK18和CA72-4水平低于姑息性切除者,差异有统计学意义(P<0.01).结论血清CK18和CA72-4水平测定对良、恶性胃癌的诊断具有重要意义;监测CK18和CA72-4的动态变化,对胃癌患者的疗效观察、预后评估有重要的价值.
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| 关 键 词： | 胃肿瘤 细胞角蛋白18 糖类抗原72-4 淋巴结转移 |
Clinical significance of serum CK18 and CA72-4 in gastric cancer |
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| Yang Shijun
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Lu Weiping
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Bao Yanmei
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Wu Xi.Clinical significance of serum CK18 and CA72-4 in gastric cancer[J].International Journal of Laboratory Medicine,2012,33(13):1593-1594. |
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| Authors: | Yang Shijun Lu Weiping Bao Yanmei Wu Xi |
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| Institution: | 1(1.Department of Nuclear Medicine;2.Department of Endocrinology,No.1 Hospital of Huai’an Affliated to Nanjing Medical University,Huai’an,Jiangsu 223300,China) |
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| Abstract: | Objective To explore the clinical significance of serum CK18 and CA72-4 for clinical diagnosis and treatment of gastric cancer.Methods Electrochemiluminescene analyzer was used to detect the content of serum CK18 and CA72-4 in 89 patients with stomach cancer and 47 patients with benign stomach diseases as control group.Results Levels of CK18 and CA72-4 in cancer group were higher than those in control group(P<0.01),and those in cancer group before surgery were higher than after surgery(P<0.01).Conclusion Detection of CK18 and CA72-4 might be with important significance for the differential diagnosis of benign and malignant stomach diseases.Dynamic monitoring of CK18 and CA72-4 might be helpful for evaluation of treatment efficiency and prognosis for gastric cancer. |
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| Keywords: | stomach neoplasms cytokeratin 18 carbohydrate antigen 72-4 lymph node metastasis |
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