肺炎克雷伯菌感染的临床分析

目的 了解该院肺炎克雷伯菌感染现状及耐药性,为临床医师合理用药提供科学依据.方法 采用回顾性调查的方法对216株肺炎克雷伯菌的标本来源及耐药性进行分析.结果 医院肺炎克雷伯菌标本主要来源依次为痰液、尿液、分泌物、血液,主要引起呼吸道感染和泌尿道感染;除亚胺培南外,产ESBLs菌株对常见抗菌剂耐药率明显高于非产ESBLs菌株.结论 产ESBLs肺炎克雷伯菌在医院感染中十分流行,多重耐药明显,医院应重视多重耐药菌监测,临床医师应积极开展病原学检查,合理使用抗菌剂,预防医院感染暴发流行.

Clinical analysis of Klebsiella pneumoniae infection

Objective To investigate distribution and antibiotic resistance of Klebsiella pneumoniae in this hospital to provide scientific basis for clinical usage of antibiotics.Methods Clinical distribution and antibiotic resistance of 216 strains of Klebsiella pneumoniae,isolated from various clinical samples,were retrospectively analyzed.Results Types of clinical samples,positive with Klebsiella pneumoniae and ranged according to the positive rate from high to low,were sputum,urine,secretions and blood,and mainly types of infection were respiratory tract infection and urinary tract infection.Except for imipenem,the strains producing extended-spectrum β-lactamase(ESBLs) were significantly with higher antimicrobial resistance than strains non-producing ESBLs.Conclusion Klebsiella pneumoniae,producing ESBLs,might be prevalent in this hospital,with significantly multi-drug resistance.More attention should be paid to monitor multi-resistant bacteria and pathogenic examination should be performed when needed to improve the rational usage of antibiotics and prevent hospital infection.