252株金黄色葡萄球菌的临床分布及耐药性分析

目的了解金黄色葡萄球菌(SA)的临床分布及耐药性特征。方法收集该院2009年1月至2010年12月临床分离的SA,采用WHONET5.4软件进行分析。结果共分离SA252株,其分离出的SA标本以痰为主,占47.62%,其次为分泌物和脓液。检出率前3位的科室为ICU、骨外科和呼吸内科。耐甲氧西林金黄色葡萄球菌(MRSA)78株,占30.95%,其中ICU的MRSA检出52株,检出率高于非ICU。除万古霉素、利奈唑胺、利福平及氯霉素对其保持较低耐药率外,对其他抗菌药物耐药率均较高。ICU内SA耐药率高于非ICU。结论通过分析SA的临床分布及耐药性特征,有利于采取措施控制NRSA的流行和指导临床用药。

Clinical distribution and drug resistance of 252 strains of Staphylococcus aureus

Objective To explore the clinical distribution and drug resistance of Staphylococcus aureus(SA) in certain hospital.Methods All clinically isolated strains of SA during January 1st,2009 to December 31st,2010 were collected.The data were analyzed by WHONET5.4 software.Results 252 strains of SA were isolated,most of which were from sputum specimens(47.62%) ,and the others were from secretion and pus specimens.The top three departments,from which the strains were get,were Intensive Care Unit(ICU) ,Department of Orthopedics and Department of Respiratory Medicine.78 stains of methicillin resistant SA(MRSA) were isolated,including 52 strains from ICU.Except vancomycin,linezolid,rifanpicin and chloromycetin.MRSA were highly resistant to other kinds of antibiotics.SA,isolated from ICU,were with higher drug resistance than those isolated from other departments.Conclusion Clinical distribution and drug resistance analysis of SA could be helpful for controlling the prevalence of MRSA and guiding clinical medication.