食管癌患者血栓弹力图临床研究

目的 应用血栓弹力图(TEG),探讨食管癌患者(EC)体内的凝血情况.方法 选取无血液疾病的150例食管癌患者为实验组,行TEG及常规凝血测定;另选取50例健康人(N)为对照组.结果 实验组反应时间(R值)为(4.14±1.90)min、凝固时间(K值)为(2.19±1.83)min,对照组R值为(5.13±1.70)min、K值为(3.19±1.63)min,两组比较,实验组明显缩短(P<0.01);实验组血栓最大幅度(MA 值)为(65.54±6.25)min、血栓弹力度(Mε值)为(229.89±65.08),对照组MA值为(52.32±5.90) min、Mε值为110.23±30.14,实验组较对照组增宽明显(P<0.01).实验组TEG结果与疾病病理分期呈正相关,实验组与对照组的常规凝血检测结果相比较差异无统计学意义(P>0.05).结论 食管癌患者体内存在病理性高凝状态,其高凝状态与病理分期有关,在常规凝血检测中不易测出.应用TEG可以明确诊断食管癌患者凝血状态,并能够进行动态观察;在判断病情、指导临床治疗和预防并发症方面比常规凝血检测更有意义.

Clinical study of blood thrombelastogrophy in patients with esophageal cancer

Objective To investigate the coagulable states in patients with esophageal cancer ( EC ) by thrombelastography ( TEG ) .Methods TEG and coagulation routine method were performed in 150patients with EC ( experimental group ) and 50 healthy individudls ( control group ) .Comparisons were made between the two groups.Results The hypercoagulable sign of the most patients with EC showed that R value [( 4.14±1.90 ) min ] and K value [( 2.19±1.83 ) min ] were obviously short and MA value [( 65.54±6.25 ) min ] and Mεvalue ( 229.89±65.08 ) were obvious wide , compared with R value [( 5.13±1.70 ) min ], K value [( 3.19±1.63 ) min )], MA value [( 52.32±5.90 ) min ] and Mεvalue ( 110.23±30.14 ) in control group ( P<0.01 ) .And the results were correlated with pathological stage.There was no difference between the experimental group and control group in the results of routine blood coagulation test ( P>0.05 ) .Conclusion Patients with EC might be with hypercoagulable sign , related with pathology and not easily be demonstrated in routine blood coagulation detection.TEG could be helpful for the diagnosis and monitoring of co- agulation sate in patients with EC , with more significance for the judgment of diseases condition , guidance of treatment and preven- tion of complications than conventional blood coagulation detection.