急性冠脉综合征患者血浆胱抑素C和超敏C反应蛋白检测的临床意义

目的 探讨检测急性冠脉综合征(ACS)患者血浆胱抑素C(CysC)和超敏C反应蛋白(hs-CRP)水平的临床意义.方法 选择108例ACS患者[急性心肌梗死(AMI)52例(AMI组),不稳定性心绞痛(UA)56例(UA组)]和54例稳定性心绞痛(SA)患者(SA组)及52例健康体检者(对照组),用乳胶增强免疫透射比浊法检测血浆CysC和hs-CRP,同时检测血清肌酐、血尿素氮等.结果 AMI组、UA组、SA组血浆CysC水平均高于对照组,肾小球滤过率(GFR)均低于对照组,AMI组、UA组血浆CysC 、hs-CRP水平均高于SA组和对照组,多支病变组血浆CysC、hs-CRP水平明显高于单支病变组(P<0.01),CysC与hs-CRP呈直线正相关(r=0.77,P<0.01).结论 血浆CysC水平能早期反映ACS患者肾功能改变,与血浆hs-CRP水平一样是反映ACS炎症程度的重要指标.

Clinical significance of plasma cystatin C and high sensitivity C-reactive protein in patients with acute coronary syndrome

Objective To explore the significance of cystatin C(CysC) and high sensitivity C-reactive protein(hs-CRP) in acute coronary syndrome(ACS).Methods 108 ACS patients,including 52 cases with acute myocardial infarction(AMI,AMI group) and 56 cases with unstable angina(UA,UA group),54 stable angina(SA) patients(SA group) and 52 healthy controls(control group) were enrolled and detected for plasma levels of CysC and hs-CRP by latex enhanced immunoturbidimetric,and plasma creatinine and urea nitrogen levels were also detected.Results Plasma CysC levels in AMI group,UA group and SA group were significantly higher than in control group,but glomerular filtration rate(GFR) was lower(P<0.01).Plasma CysC and hs-CRP levels in AMI group and UA group were significantly higher than in SA group and control group,and those in patents with multi-vessel disease were significantly higher than in patients with single-vessel disease(P<0.01).Plasma level of CysC was linearly correlated with hs-CRP(r=0.77,P<0.01).Conclusion Plasma CysC could early reflect the changes of renal function in patients with ACS,and could be an important index to reflect the inflammation of ACS,just as hs-CRP.