AFP、AFU、GGT、ALP及CA19-9联合检测对肝癌的诊断价值

目的 探讨甲胎蛋白(AFP)、α-L-岩藻糖苷酶(AFU)、γ-谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)以及糖类抗原CA19-9(CA19-9)对肝癌的诊断价值.方法 检测GGT、ALP、AFU采用速率法,检测AFP、CA19-9采用电化学发光免疫分析法,分别检测原发性肝癌组(46例)、转移性肝癌组(37例)、健康对照组(64例)血清GGT、ALP、AFU、AFP、CA19-9水平,并对结果进行统计学分析.结果 原发性肝癌组、转移性肝癌组血清GGT、AFU、ALP、CA19-9水平显著高于健康对照组(P<0.05),原发性肝癌组血清AFP、AFU水平显著高于健康对照组和转移性肝癌组(P<0.05),转移性肝癌组血清AFP水平与健康对照组比较,差异无统计学意义;各检测指标诊断原发性肝癌和转移性肝癌的阳性率分别为GGT 95.7%、94.6%,ALP 91.3%、78.4%,AFU 78.3%、21.6%,AFP 93.5%、45.9%,CA19-9 56.5%、59.5%,与健康对照组阳性率比较,差异有统计学意义(P<0.05).5项指标联合检测对原发性肝癌和转移性肝癌的阳性率分别为100.0%、97.3%,与健康对照组比较,差异有统计学意义(P<0.05).结论 GGT、ALP、AFU、AFP及CA19-9联合检测可以明显提高诊断肝癌的阳性率和准确性.

Diagnostic significance of combined detection of AFP, AFU, GGT, ALP and CA19-9 in hepatocellular carcinoma

Objective To investigate the diagnostic value of α-fetoprotein(AFP),α-L-fucosidase(AFU),glutamyl aminotransferase(GGT),alkaline phosphatase(ALP) and carbohydrate antigen CA19-9(CA19-9) in hepatocellular carcinoma.Methods Serum levels of GGT,ALP,AFU,AFP and CA19-9 were detected in 46 cases of primary hepatocellular carcinoma(PHC) patients(PHC group),37 cases of metastatic hepatocellular carcinoma(MHC) patients(MHC group) and 64 cases of healthy controls(HC group).All results were statistically analyzed.Results Serum levels of GGT,AFU,ALP and CA19-9 in PHC group and MHC group were significantly higher than those in HC group(P<0.05),serum levels of AFP and AFU in PHC group were significantly higher than those in HC group and MHC group(P<0.05),and the difference of serum AFP level was with no statistical significance between MHC group and HC group.Positive rates of GGT,ALP,AFU,AFP and CA19-9 for the diagnosis of PHC were 95.7%,91.3%,78.3%,93.5% and 56.5%,and for the diagnosis of MHC were 94.6%,78.4%,21.6%,45.9% and 59.5%,which were statistically different with those in HC groups(P<0.05).The positive rates of combined detection of the five indicators for PHC and MHC were 100.0% and 97.3%,respectively,which were significantly different with that in HC group(P<0.05).Conclusion Combined detection of GGT,ALP,AFU,AFP and CA19-9 could improve the positive rate and accuracy in diagnosis of hepatocellular carcinoma.