A randomized, parallel study of the safety and efficacy of 45 mg primaquine versus 75 mg bulaquine as gametocytocidal agents in adults with blood schizonticide-responsive uncomplicated falciparum malaria [ISCRTN50134587] |
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| Authors: | NJ Gogtay KD Kamtekar SS Dalvi SS Mehta AR Chogle U Aigal NA Kshirsagar |
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| Affiliation: | (1) Department of Clinical Pharmacology, Seth G.S. Medical College and K.E.M hospital. Parel, Mumbai, 400 012, India;(2) Department of Medicine, Seth G.S Medical College & K.E.M Hospital. Parel, Mumbai, 400012, India;(3) Kasturba Hospital for Infectious diseases, Sane Guruji Marg, Mumbai, 400011, India |
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| Abstract: | Background The WHO recommends that adults with uncomplicated P. falciparum successfully treated with a blood schizonticide receive a single dose of primaquine (PQ) 45 mg as a gametocytocidal agent. An earlier pilot study suggested that 75 mg of bulaquine (BQ), of which PQ is a major metabolite, may be a useful alternate to PQ. |
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