Re: Yang, J. and Duerksen-Hughes, P. (1998) A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis, 19, 11171125. |
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| Authors: | Stenius, Ulla Hogberg, Johan Duerksen-Hughes, P. |
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| Affiliation: | Institute of Environmental Medicine, Karolinska Institutet, Box 210, S-171 77 Stockholm, Sweden |
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| Abstract: | Dear Sir, In a recent issue of the Journal, Yang and Duerksen-Hughes presenta new in vitro approach for identifying genotoxic carcinogens.In this study they used p53 induction in vitro as an indicatorof genotoxic damage. The authors suggest that this endpointcould be used as an effective tool for identifying environmentalcarcinogens. In our opinion, p53 induction has clear weaknesses as an endpointfor in vitro genotoxicity testing. It is induced by many types |
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