The Crystal and Molecular Structures of N4-(5-Bromosalicylidene)-N1-(3,4-dimethyl-5-isoxazolyl)sulfanilamide |
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Authors: | Reijo Hmlinen Maire Lehtinen Urho Turpeinen |
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Institution: | Reijo Hämäläinen,Maire Lehtinen,Urho Turpeinen |
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Abstract: | The structure of the title compound was determined by X-ray analysis. Medicinal compounds with Schiff base structure have been widely synthesized and investigated in recent years. The functional group-CH?N- of the Schiffbases has been shown to have considerable biological importance1) . Many compounds with such a structure have important analgesic, anti-inflammatory, antibiotic, antimicrobial and especi ally anticancer activities2-8). Medicinal sulphonamides, having a primary amino group in their molecule, react very easily with salicylaldehyde or its derivatives9). Information about the exact structure of the reac tion products is rather scanty, however, even though the formation reaction of the base has been utilized in many analytical pr ocedures for medicinal sulphonamides9-12) and many such Schiff bases have been found to possess good bac teriostatic properties13-14). |
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