黏膜免疫系统的淋巴细胞归巢

黏膜在人体内分布十分广泛,在呼吸道、肠道及泌尿生殖道都有分布。黏膜免疫是免疫系统中的一个特殊组成部分,不同的黏膜部位可通过淋巴细胞归巢发生关联,产生共同的免疫效应。淋巴细胞归巢是一个多步骤的过程,涉及一系列的整合素、选择素、趋化因子及其受体家族等。不同部位不同淋巴细胞的归巢可能由不同的归巢受体所介导。

Lymphocyte homing to the mucosae

Mucosa are widely distributed in the human body,coveting the surface of the respiratory,intestinal and urinary tract.Mucosal immune system is a particular part of the whole immune system.Different parts of mucosa can be connected by lymphocyte homing,which results in a common immune response.Lymphocyte homing is a multi-step process involving a series of integrias,selectins,chemokines and their receptor family,etc.In different mucosa,there may be different homing receptors responsible for the homing process.