| 同源异型盒基因-1与非综合征型多数牙先天性缺失 |
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| 引用本文： | 方静娴,宋光泰,叶晓茜.同源异型盒基因-1与非综合征型多数牙先天性缺失[J].国际口腔医学杂志,2009,36(2). |
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| 作者姓名： | 方静娴 宋光泰 叶晓茜 |
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| 作者单位： | 武汉大学口腔医院儿童口腔科,口腔生物医学工程教育部重点实验室,武汉大学,湖北,武汉,430079 |
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| 摘 要： | 牙缺失是常见的颌面发育异常之一,在恒牙列中的发病率高达20%,而其表现程度也存在较大差异.在过去的数十年中,遗传连锁和分子生物学研究使得部分综合征和非综合征型牙缺失的基因突变得以定位.尽管作用机制尚未明了,但现已知其中所涉及的重要突变因子包括了编码转录因子的同源异型盒基因(msx)-1、双链复合蛋白基因(pax)-9和轴抑制基因(axin)-2.下面从近年来国内外有关先天性牙缺失的病例报告、致病基因分析以及分子生物学和生物化学等研究方面就msx-1基因与非综合征型牙缺失的关系进行综述.
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| 关 键 词： | 多数牙先天性缺失 同源异型盒基因-1 非综合征 |
Muscle segment homeobox gene-1 and non-syndromic hypodontia |
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| FANG Jing-xian,SONG Guang-tai,YE Xiao-qian.Muscle segment homeobox gene-1 and non-syndromic hypodontia[J].Journal of International Stomatology,2009,36(2). |
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| Authors: | FANG Jing-xian SONG Guang-tai YE Xiao-qian |
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| Institution: | Dept. of Pediatric Dentistry;College of Stomatology;Wuhan University;Wuhan 430079;China;Key Labo-ratory of Oral Biomedical Engineering of Ministry of Education;China |
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| Abstract: | Tooth agenesis is the most common craniofacial malformation. Its prevalence in permanent dentition reaches 20% and its expressivity ranges from only one tooth,usually a third molar,to the whole dentition. Genetic linkage and molecular biology studies have allowed,in the last decade,the identification of mutations responsible for some patterns of syndromic and non-syndromic tooth agenesis. The molecular basis of the defect is not com-pletely understood,despite identification of several mutations in muscle se... |
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| Keywords: | hypodontia muscle segment homeobox gene-1 non-syndromic |
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