The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function |
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| Authors: | Shevach Ethan M Tran Dat Q Davidson Todd S Andersson John |
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| Affiliation: | Laboratory of Immunology, NIAID, NIH, Bethesda, MD 20892, USA. EShevach@niaid.nih.gov |
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| Abstract: | Stimulation of mouse CD4+ T cells in the presence of TGF-beta results in the expression of Foxp3 and induction of Treg function. Stimulation of human CD4+ T cells under similar conditions results in the expression of Foxp3, but the cells lack regulatory cell function. TGF-beta expressed on the surface of Treg also induces Foxp3 expression and Treg function in responder cells. Both of these mechanisms may play a role in vivo in the induction of antigen-specific extra-thymic Treg. |
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| Keywords: | Foxp3 IL‐2 Regulatory T cells TGF‐β |
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