Abeta(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau |
| |
Authors: | Ghribi Othman Prammonjago Patcharin Herman Mary M Spaulding Natalie K Savory John |
| |
Affiliation: | Department of Pathology, Health Sciences Center, University of Virginia, P.O. Box 800214, Charlottesville, VA 22908, USA. og2p@virginia.edu |
| |
Abstract: | Administration of Abeta(1-42) into the rabbit brain induces apoptosis and phosphorylation of tau. These Abeta effects correlate with the activation of JNK and ERK, but not of p38. Treatment with 7 mM lithium inhibits apoptosis, modulates JNK and ERK and does not affect the phosphorylation of tau. Our results demonstrate that lithium, at this dose, effectively inhibits the Abeta-induced apoptosis but has no effect on tau phosphorylation, and that MAP kinases are not involved in the phosphorylation of tau. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|