| 原发性慢性肾小球肾炎患者血浆6一Keto一PGF_(la)、TXB_2的变化 |
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| 引用本文： | 李一文,陈伯煊,张淑慎,李荣亨,张晓恒,高渝军. 原发性慢性肾小球肾炎患者血浆6一Keto一PGF_(la)、TXB_2的变化[J]. 重庆医学, 1991, 0(5) |
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| 作者姓名： | 李一文 陈伯煊 张淑慎 李荣亨 张晓恒 高渝军 |
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| 作者单位： | 浙江中医学院附属医院(李一文)，重庆医科大学附属第一医院(陈伯煊，张淑慎，李荣亨，张晓恒)，重庆医科大学附属第一医院(高渝军) |
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| 摘 要： | 本文用放射免疫方法,测定了48例原发性慢性肾小球肾炎患者血浆6一Keto一PGF_(12)TXB_2的含量及T/6的比值,发现肾炎各型中血浆6一Keto—PGF_(12)含量均明显降低;TXB_2含量在肾病型明显增高,在肾功不全组明显降低。T/6比值在肾功正常各型中明显增高,在肾功不全组无明显改变。结果提示肾炎病变发展过程及,高凝状态的形成中,PCI_2-TXA_2的平衡失调起着重要的作用。为用能增加血浆中PGI_2或减少TXA_2产生的药物来治疗肾炎,提供依据。
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| 关 键 词： | 前列环素(PGI_2) 6-酮-前列腺素F_(l(?))(6-Keto-PGF_(l(?))) 血栓素A_2(TXA_2) 血栓素B_2(TXB_2) |
THE INVESTIGATION OF PIASMA 6-KETO-PGFLa AND TXB, IN PRIMARY CIIRONIC GLOMERULON EPHRITIS |
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| Li Yi-wen et alDept. of TCM,The First AffiliatedHospital,Chongqing University of Medical sciences. THE INVESTIGATION OF PIASMA 6-KETO-PGFLa AND TXB, IN PRIMARY CIIRONIC GLOMERULON EPHRITIS[J]. Chongqing Medical Journal, 1991, 0(5) |
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| Authors: | Li Yi-wen et alDept. of TCM The First AffiliatedHospital Chongqing University of Medical sciences |
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| Abstract: | Plasma concentration of 6-Keto-PGFla(6-K-P) ,TXB2(T)and T/6-K-P were measured by RIA method in 48 cases of chronic glomerulonephritis(CGN)and 30 cases in control group.PiasmaG-K - P decreased in all patients(p<0. 05,0. 01). TXB2 increased significantly in patients with nephrotic syndrome (p<0. 01),but decreased in patients with renal function insufficiency(RFI)(P<0. 01). T/6 - K - P were increased in all cases (p<0. 05)except the RFI patients.The results showed that pathologic progression and hypercoagulation in CGN patients were closely interrelated to the unbalance of PGI2 -TXA2 and increase of T/6 -K -P. In RFI patients, the T/6 -K -P ratio may affect the presence of hypercoagulation of hypocoagulation. |
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