Crotapotin induced modification of T lymphocyte proliferative response through interference with PGE2 synthesis. |
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| Authors: | Flavia Garcia Marcos H Toyama Fabiano R Castro Patrícia L Proen?a Sergio Marangoni Leonilda M B Santos |
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| Affiliation: | Neuroimmunology Unit, Department of Microbiology and Immunology, Institute of Biology, University of Campinas, UNICAMP, Campinas, SP 13083-970, Brazil. |
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| Abstract: | The immunosuppressive property has been demonstrated for the venom of the Crotalus durissus terrificus. Using a simple, novel method for obtaining crotapotin and phospholipase A2 isoforms from venom, it was possible to demonstrate that the addition of crotapotin to cultures of isolated lymphocytes resulted in a significant inhibition of the cellular proliferative response to Concanavalin A. This reduction in blastogenic response of lymphocytes is accompanied by a significant increase in the production of PGE2 by macrophages. This effect on the innate immune response suggests that this compound may modify the subsequent adaptative immune response. |
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| Keywords: | T cell activation Inflammatory response Crotapotin |
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